Mitochondrial DNA damage, oxidative stress, and atherosclerosis: where there is smoke there is not always fire.
نویسندگان
چکیده
منابع مشابه
Cigarette smoke exposure and hypercholesterolemia increase mitochondrial damage in cardiovascular tissues.
BACKGROUND A shared feature among cardiovascular disease risk factors is increased oxidative stress. Because mitochondria are susceptible to damage mediated by oxidative stress, we hypothesized that risk factors (secondhand smoke and hypercholesterolemia) are associated with increased mitochondrial damage in cardiovascular tissues. METHODS AND RESULTS Atherosclerotic lesion formation, mitocho...
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BACKGROUND Oxidative stress associated with cardiovascular disease (CVD) risk factors contributes to disease development. However, less is known whether specific subcellular components play a role in disease susceptibility. In this regard, it has been previously reported that vascular mitochondrial damage and dysfunction are associated with atherosclerosis. However, no studies have determined w...
متن کاملMaternal L-Carnitine Supplementation Improves Brain Health in Offspring from Cigarette Smoke Exposed Mothers
Maternal cigarette smoke exposure (SE) causes detrimental changes associated with the development of chronic neurological diseases in the offspring as a result of oxidative mitochondrial damage. Maternal L-Carnitine administration has been shown to reduce renal oxidative stress in SE offspring, but its effect in the brain is unknown. Here, we investigated the effects of maternal L-Carnitine sup...
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عنوان ژورنال:
- Circulation
دوره 128 7 شماره
صفحات -
تاریخ انتشار 2013